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New cationic polyphosphazene compound, polyphosphazene drug conjugate compound and process for preparing the same
New cationic polyphosphazene compound, polyphosphazene drug conjugate compound and process for preparing the same
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机译:新型阳离子聚磷腈化合物,聚磷腈药物共轭化合物及其制备方法
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摘要
The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.
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