SRM / MRM Assay of Insulin Receptor Substrate 1 Protein (IRS1)

摘要

The present invention is related to a method for selecting a treatment for a human patient suffering from cancer, comprising: measuring by mass spectrometry the amount of an IRS1 fragment peptide in a protein digest prepared from a sample of formalin fixed tumor tissue from the patient and, optionally, calculating the level of IRS1 protein in said sample; and selecting a treatment based on the presence, absence, or amount of said IRS1 fragment peptide or the level of IRS1 protein in said sample, wherein the IRS1 fragment peptide is SEQ ID NO:70 or SEQ ID NO:76.