首页>
外国专利>
INHIBITORS OF 17.BETA.-HSD1, 17.BETA.-HSD3 AND 17.BETA.-HSD10.
INHIBITORS OF 17.BETA.-HSD1, 17.BETA.-HSD3 AND 17.BETA.-HSD10.
展开▼
机译:17.BETA-HSD1、17BETA-HSD3和17.BETA-HSD10的抑制剂。
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present application discloses 17ß hydroxy steroid dehydrogenase (17ß HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17ß HSDl inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17ß HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17ß HSDl and 17ß HSD3 that have a spiro-morpholine substituent at C20.
展开▼