MARKER FOR DIAGNOSING FORELIMB-GIRDLE MUSCULAR ANOMALY IN MAMMAL, AND DETECTION METHOD USING THE SAME

摘要

The present invention uses an isolated polynucleotidehaving a part or whole of GFRA1 gene, mutant GFRA1 protein,and mRNA encoding the mutant GFRA1 protein, each of whichincludes a loss-of-function mutation of GFRA1, as markers fordiagnosing an animal as affected by forelimb-girdle muscularanomaly or as a carrier of forelimb-girdle muscular anomaly.In addition, an isolated polynucleotide comprising one ormore selected from the group consisting of MOK2630, MOK2637,SNP B, and SNP D can be used as markers for diagnosingwhether a bovine animal is affected by forelimb-girdlemuscular anomaly or whether a bovine animal is a carrier offorelimb-girdle muscular anomaly.