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NUCLEAR STRESS RESPONSE IN MOTOR NEURON DISEASE AND OTHER NEUROLOGICAL DISEASES
NUCLEAR STRESS RESPONSE IN MOTOR NEURON DISEASE AND OTHER NEUROLOGICAL DISEASES
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机译:运动神经元疾病和其他神经疾病中的核应力反应
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摘要
The invention relates to diagnosis, prognosis and treatment of neurological diseases. In one embodiment, the present invention provides methods and kits that diagnose whether a subject has a neurological disease or susceptibility to a neurological disease by evaluating nuclear stress body (NSB) levels. Further described are methods and kits that prognose a neurological disease in a subject by monitoring changes in NSB levels. Also described are methods and kits that treat neurological diseases by administering one or more inhibitors of NSB signaling to a patient, as well as compositions containing one or more NSB signaling inhibitors. Medical conditions suitable with various embodiments of the invention include but are not limited to ALS, FTLD, dementia and AD.
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