METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITHIN A CELL

摘要

In ones aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or viral replication in a host cell. In another aspect, the invention provides methods for treating patients suffering from infection, particularly infection with HIV.