首页> 外国专利> USE OF A BISAMIDE DERIVATIVE OF MALONIC ACID FOR TREATING ALLERGIC DISEASES AND OTHER DISEASES IN HUMANS AND ANIMALS

USE OF A BISAMIDE DERIVATIVE OF MALONIC ACID FOR TREATING ALLERGIC DISEASES AND OTHER DISEASES IN HUMANS AND ANIMALS

机译:丙二酸双酰胺衍生物对人类和动物过敏性疾病和其他疾病的治疗

摘要

The invention relates to therapy of diseases associated with the activity of histamine receptors, in particular therapy of allergic diseases, preferably therapy of perennial and persistent allergic rhinitis, pruritus, and also a series of other diseases associated with the activity of histamine receptors of type three and/or four, by means of the use of the compound NN'-bis(2-(1Н-imidazol-5-yl)ethyl)malonamide (I). Said compound, and also the pharmaceutically acceptable salts, hydrates and solvates thereof, are antagonists of histamine receptors of type three and/or four. The present invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of compound I.
机译:本发明涉及与组胺受体活性有关的疾病的治疗,特别是变应性疾病的治疗,优选常年和持续性变应性鼻炎,瘙痒症的治疗,以及与三型组胺受体活性有关的一系列其他疾病和/或四种,通过使用化合物NN'-双(2-(1-(1_-咪唑-5-基)乙基)丙二酰胺(I)。所述化合物及其药学上可接受的盐,水合物和溶剂化物是三和/或四型组胺受体的拮抗剂。本发明还涉及包含治疗有效量的化合物I的药物组合物。

著录项

  • 公开/公告号WO2019226082A1

    专利类型

  • 公开/公告日2019-11-28

    原文格式PDF

  • 申请/专利权人 PHARMENTERPRISES ALLERGY LLC;

    申请/专利号WO2019RU50066

  • 发明设计人 NEBOLSIN VLADIMIR EVGENIEVICH;

    申请日2019-05-22

  • 分类号C07D403/12;A61K31/4178;A61P11;A61P37;

  • 国家 WO

  • 入库时间 2022-08-21 11:14:36

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