CARBONYL REDUCTASE MUTANT AND USE THEREOF IN REDUCTION OF CYCLOPENTANEDIONE COMPOUND

摘要

Provided are a carbonyl reductase mutant protein and the use thereof in reduction of a cyclopentanedione compound. The mutant protein is a non-native protein, and can be used to catalyze a cyclopentanedione compound to generate a cyclopentanone alcohol. The mutant protein is mutated in four or more core amino acids, related to the enzyme catalytic activity, of a wild type carbonyl reductase.