STRONG BASE-INITIATED N-CARBOXYANHYDRIDE RAPID RING-OPENING POLYMERISATION METHOD

摘要

The present invention relates to a strong base-initiated N-carboxyanhydride rapid ring-opening polymerisation method. Specifically, the method comprises steps of: performing a polymerisation reaction with one or more amino acid N-carboxyanhydride monomers in an organic solvent in the presence of an initiator, so as to form an amino acid polymer, wherein the initiator is selected from the following group: LiHMDS, NaHMDS, KHMDS, or a combination thereof. The method significantly increases the speed of traditional NCA polymerisation and prepares a long-chain polymer, and the prepared amino acid polymer may be used as an anti-bacterial material, an anti-tumour material, a tissue engineering scaffold or a self-assembling material.