AMINOBISPHOSPHONATES AS LATENCY REVERSING AGENTS AND COMBINATION TREATMENTS FOR HIV CURE

摘要

The present disclosure provides novel methods to cure HIV. In particular aminobisphosphonates are disclosed as latency reversing agents (LRAs), and methods to cure HIV by administering to a subject a combination of bisphosphonates and γδ T cells are provided. In some embodiments, these interventions may be combined with other latency reversing agents, e.g., histone deacetylase (HD AC) inhibitors, and other immunotherapeutics for HIV clearance (e.g., broadly HIV -neutralizing antibodies).