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MART-1(27-35) EPITOPE-SPECIFIC T CELL RECEPTOR
MART-1(27-35) EPITOPE-SPECIFIC T CELL RECEPTOR
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机译:MART-1(27-35)表位特异性T细胞受体
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摘要
Provided is a MART-1(27-35) epitope-specific T cell receptor, comprising an α chain and a β chain. The α chain comprises three complementary determining regions, respective sequences thereof being positions 61-66, positions 84-89, and positions 124-136 of SEQ ID No.3. The β chain comprises three complementary determining regions, respective amino acid sequences thereof being positions 46-50, positions 68-73 and positions 112-125 of SEQ ID No.4. A T cell expressing the TCR can effectively recognize a MART-1(27-35) epitope polypeptide supported on a T2 cell and secrete IFN-γ, thereby demonstrating the functionality of the receptor. Use of the TCR with a relevant drug target allows for effective drug development.
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机译:提供了一种MART-1(27-35)表位特异性T细胞受体,其包含α链和β链。 α链包含三个互补决定区,其各自的序列是SEQ ID No.3的位置61-66,位置84-89和位置124-136。 β链包含三个互补决定区,其各自的氨基酸序列为SEQ ID No.4的位置46-50,位置68-73和位置112-125。表达TCR的T细胞可以有效识别支持在T2细胞上的MART-1(27-35)表位多肽并分泌IFN-γ,从而证明该受体的功能。将TCR与相关的药物靶标结合使用可有效开发药物。
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