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PREPARATION METHOD FOR DOUBLE-SENSITIVITY CELLULOSE-BASED AEROGEL
PREPARATION METHOD FOR DOUBLE-SENSITIVITY CELLULOSE-BASED AEROGEL
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机译:双敏纤维素基气凝胶的制备方法
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摘要
Disclosed is a preparation method for a double-sensitivity cellulose-based aerogel. Dialdehyde cellulose, a dialdehyde cellulose/dimethylaminoethyl methacrylate copolymer, and a dialdehyde cellulose/dimethylaminoethyl methacrylate/polymine copolymer are prepared successively, then freezing drying is performed, and a product can be obtained; the product is the double-sensitivity cellulose-based aerogel, the accumulated adsorbing capacity of the aerogel reaches 250 mg/g, and the accumulated releasing amount of the aerogel in a 0.2% NaC (pH3) solution, a 0.05 mol/L NaH2PO4 (pH=3-8) solution, or a NaOH (pH8) solution reaches 63-90%; the obtained product has the advantages that the mass is low, the biocompatibility is good, the porosity is high, and pH/temperature double-sensitivity is high, and the like; the product can be used as a biomedical material, and has a wide application prospect in drug sustained release, wound dressings and other aspects.
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机译:本发明公开了一种双敏纤维素基气凝胶的制备方法。依次制备二醛纤维素,二醛纤维素/甲基丙烯酸二甲氨基乙基酯共聚物和二醛纤维素/甲基丙烯酸二甲基氨基乙基酯/多胺共聚物,然后进行冷冻干燥,得到产物。该产品为双敏纤维素基气凝胶,气凝胶的累积吸附量达到250 mg / g,在0.2%NaC(pH <3)溶液中气凝胶的累积释放量为0.05 mol / L NaH 2 Sub> PO 4 Sub>(pH = 3-8)溶液或NaOH(pH> 8)溶液达到63-90%;所得产品具有质量低,生物相容性好,孔隙率高,pH /温度双敏感性高等优点。该产品可用作生物医学材料,在药物缓释,伤口敷料等方面具有广阔的应用前景。
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