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ARTIFICIAL INTELLIGENCE MODEL FOR PREDICTING EFFECT OF TEST SUBSTANCE ON HUMANS

机译:预测物质对人类影响的人工智能模型

摘要

A method for training an artificial intelligence model includes training the artificial intelligence model by inputting into the artificial intelligence model a first training data group and either second training data or a second training data group, wherein the first training data group is configured from a group of data indicating behavior of a biomarker in each of one or a plurality of different organs, the one or plurality of different organs being harvested from non-human animals to which a plurality of existing substances having known effects on humans have been individually administered, and the second training data are configured from information relating to known effects on humans, acquired for each of the plurality of known substances administered to the non-human animals, and wherein the artificial intelligence model predicts one or a plurality of effects of a test substance on humans, from a group of data indicating the behavior of a biomarker in one or plurality of organs corresponding to the organs harvested when the first training data group is generated, said harvested organs being one or more different organs of non-human animals to which the test substance has been administered, and the artificial intelligence model predicts effects, such as effectiveness and side effects, of the test substance on humans using the artificial intelligence model that has been trained using the training method.
机译:一种用于训练人工智能模型的方法,包括通过将第一训练数据组和第二训练数据或第二训练数据组输入到人工智能模型中来训练人工智能模型,其中,第一训练数据组由一组数据,指示生物标记在一个或多个不同器官中的每个器官中的行为,该一个或多个不同器官是从非人类动物中收获的,已向该人类动物分别施用了多种对人类具有已知作用的现有物质,并且第二训练数据是从与对人类的已知作用有关的信息中配置的,该信息是从对非人类动物施用的多种已知物质中获取的,并且其中,人工智能模型可以预测一种或多种受试物质对人类的作用。从一组指示一个或多个器官中生物标志物行为的数据中对应于生成第一训练数据组时收获的器官,所述收获的器官是已对其施用了测试物质的非人类动物的一个或多个不同器官,并且人工智能模型可预测效果,例如有效性和副作用使用已经通过训练方法训练的人工智能模型,测试物质对人类的影响。

著录项

  • 公开/公告号WO2020021857A1

    专利类型

  • 公开/公告日2020-01-30

    原文格式PDF

  • 申请/专利权人 KARYDO THERAPEUTIX INC.;

    申请/专利号WO2019JP21735

  • 发明设计人 SATO NARUTOKU;

    申请日2019-05-31

  • 分类号G16B40/20;C12Q1/6869;G01N33/15;G01N33/50;

  • 国家 WO

  • 入库时间 2022-08-21 11:13:41

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