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Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy
Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy
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机译:溶瘤性单纯疱疹病毒(oHSV)专性载体的构建及用于癌症治疗的构建体
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摘要
An obligate oHSV vector comprising modified viral DNA genome is provided. A recombinant oHSV-1 construct comprising the obligate oHSV vector and a heterologous nucleic acid sequence encoding an immunostimulatory and/or immunotherapeutic agent is also provided. Compositions comprising the recombinant oHSV-1 construct can be used for treating cancers.
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