IMMUNOGEN FOR BROAD-SPECTRUM INFLUENZA VACCINE AND APPLICATION THEREOF

摘要

The present invention provides a novel influenza immunogen, having a sequence comprising an amino acid sequence shown in SEQ ID No. 1 or SEQ ID No. 2, an immunogenic fragment thereof, or a combination thereof. Further, the present invention also provides a recombinant vector vaccine utilizing the immunogen and an application of an immunization method thereof in an influenza vaccine. The invent sequentially applies various vector vaccines expressing the novel influenza immunogen, and utilizes a combination of systemic immunity and local immunity, so as to locally induce a high level of T cell immune response in the respiratory tract, thereby providing broad-spectrum protection against various influenza virus infections.