PRE-LOADABLE DRIED BIOLOGICAL HEART VALVE AND PREPARATION METHOD THEREOF

摘要

Disclosed are a pre-loadable dried biological heart valve and a preparation method thereof. The preparation method comprises: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, followed by subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide/N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium having undergone the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, followed by drying the pericardium having undergone the second cross-linking, thus obtaining the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and can rapidly flatten out in a simulated bending test.