The present disclosure presents a trajectory array guide system (19) for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory. The trajectory array guide system (19) can comprise a base (450), an array guide (320), an imaging unit (360), and an elongated handle (440) configured for connection with a stereotaxic navigation system. The present disclosure presents a method of using a trajectory array guide system (19) for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory.
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