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Conformationally stabilized RSV pre-fusion F proteins
Conformationally stabilized RSV pre-fusion F proteins
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机译:构象稳定的RSV融合前F蛋白
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摘要
The present invention provides mutant RSV F molecules, such as those that can be, or are stabilized, in a pre-fusion conformation by the introduction of one or more DT cross-links. The present invention also provides methods of making such mutant RSV F molecules, compositions comprising such mutant RSV F molecules, and methods of use of such mutant RSV F molecules, for example in vaccination methods, therapeutic methods, and antibody production methods.
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