COMPOUND LIBRARY AND METHOD FOR PRODUCING COMPOUND LIBRARY

摘要

The present invention provides a method for producing a compound library that comprises at least two kinds of cyclic compounds represented by formula (I), the compound library production method comprising a step for: allowing a macrocyclization enzyme to act in a test tube on a least two kinds of peptides represented by formula (II) (II) LP-X-(Xa)_m-Y-Z [in formula (II), X represents a group represented by formula (1), Y is a peptide residue comprising four amino acids and/or analogs thereof and contains a group represented by formula (2) (R¹ and B¹ are the same as defined above and R³ represents a hydrogen or hydrocarbon group), and LP represents a peptide residue that may or may not be present and when present, comprises 1-100 amino acids and/or analogs thereof]; and when LP is present, forming a nitrogen-containing six-membered ring A while eliminating LP to form at least two kinds of cyclic compounds represented by formula (I).