Methord on anti - inflammatory and anti - tumor effects of gelatin - based on pH - responsive drug - loaded nanoparticles

摘要

#$%^&*AU2019101195A420200116.pdf#####ABSTRACT The invention lies in the field of nanomedicine. It is able to release anti-inflammatory drug and anti-tumor drug according two different environment: the inflammatory condition in early stage of cancers, and the acid condition which has specific pH value after appearing of tumour cells.Gelatin as one kind of nano-drug carrier is a polysaccharide which can be absorbed after releasing all nano-drugs. Poly(ethylene glycol) as a polymer material that can modify nano-drugs is able to extend circulatory time of doxorubicin and aspirin, enhance stability and reduce toxicity. At precancerous, aspirin will be released slowly to resist inflammation. When tumor cell appear at a more advance stage, doxorubicin release from Gel to achieve anti-tumor effect. After all those step, poly(ethylene glycol) could be expelled from body.