METHODS AND COMPOSITIONS FOR DETERMINATION OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND NON-ALCOHOLIC STEATOHEPATITIS (NASH)

摘要

The disclosure provides methods for identifying non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in a subject. The disclosure provides a method of identifying nonalcoholic fatty liver disease (NAFLD) in a subject, comprising (a) obtaining a biological sample from the subject; (b) measuring the level of a plurality of bioactive lipids selected from the group consisting of at least dhk-PGD2, 5-HETE and ceramide P-d18:1/20:5, and optionally one or more additional compounds selected from the group consisting of CER P-d18:1/18:0, SM 36:3, LPE 18:1, LPC 0-18:0, SM 34:3, PC 42:10, PC 0-, LPC 18:2, PC 42:9, PC 0-42:2, and PC 40:0; and (c) comparing the levels of dhk-PGD2, 5-HETE and ceramide P-d18:1/20:5 in the biological sample obtained from the subject to a control sample, wherein a difference in the levels is indicative of NAFLD.