Use of electrochemical impedance spectroscopy (EIS) in continuous glucose monitoring

摘要

#$%^&*AU2019203620B220200730.pdf#####ABSTRACT A method for real-time self-calibration of a sensor, said sensor including sensor electronics, a microcontroller, and at least one working electrode, the method comprising: performing, by said 5 microcontroller, an electrochemical impedance spectroscopy (EIS) procedure for said at least one working electrode to obtain values of at least one impedance-based parameter for the at least one working electrode; periodically repeating, by said microcontroller, said EIS procedure for said working electrode to obtain additional values of said at least one impedance-based parameter; calculating, by said microcontroller, values of at least one ElS-based parameter 10 based on said obtained values and additional values of the at least one impedance -based parameter; monitoring the calculated values of said at least one ElS-based parameter for variations in said calculated values; and adjusting, by said microcontroller, a calibration factor for said sensor based on said variations in the calculated values. 15