METHODS AND COMPOSITIONS FOR THE TREATMENT OF MUCOSAL LESIONS

摘要

The present invention relates to the treatment of mucosal lesions in the gastrointestinal tract. Specifically, methods and pharmaceutical compositions are provided for the treatment of a mucosal lesion associated with a disorder of the gastrointestinal tract. The methods comprise administering to a subject an effective amount of an agent which decreases expression and/or activity of Flightless I in the subject. Treatment of disorders such as inflammatory bowel disease (including ulcerative colitis and Crohn's disease), coeliac disease, peptic ulcer disease, and regional ileitis are contemplated. Methods and associated kits for diagnosing a disorder of the gastrointestinal tract or for assessing the progression of a disorder of the gastrointestinal tract in a subject are also provided.