SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE USING LACTATE AS AN INDICATOR

摘要

#$%^&*AU2019213320C120200514.pdf#####ABSTRACT The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of an organ care system heart perfusion device to evaluate 1) the overall perfusion status of an isolated heart, 2) the metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved of oxygen and to metabolize/utilize lactate for energy production when they are well perfused with oxygen.1/68 fT CD - ~ T .-r', 12