NON HUMAN MAMMAL MODELS FOR NON-ALCOHOLIC FATTY LIVER DISEASE

摘要

The invention provides a method of producing a non-human mammal model, comprising providing a 24αβΝΟD non-human mammal comprising at least one functioning RAG2 allele; and exposing the 24αβΝΟD non-human mammal comprising at least one functioning RAG2 allele to metabolic stress by maintaining the non-human mammal on a high fat diet, thereby generating the non-human mammal model. The model shows a pathology of non-alcoholic fatty liver disease (NAFLD) similar to that of the corresponding human condition. With the model mammal of the invention, it is possible to efficiently screen for substances for treating or preventing NAFLD, and to effectively evaluate the efficacy of medicinal substances. The invention also relates to the methods of using the non-human mammal model for screening and evaluation of therapeutic substances.