Preparation Method of Curcumin-Cyclodextrin Supramolecular Inclusion Compound

摘要

#$%^&*AU2020101225A420200806.pdf#####Abstract of Description The invention provides a preparation method of curcumin-cyclodextrin supramolecular inclusion compound, which comprises the following steps: Si. Under alkaline conditions, carrying out polymerization reaction on p-cyclodextrin and epichlorohydrin to generate cyclodextrin polymer; S2. Mixing cyclodextrin polymer and curcumin, and taking water as a solvent to obtain a water-soluble curcumin supramolecular inclusion compound. The cyclodextrin polymer provided by the invention has good water solubility and can wrap more curcumin, and is a good embedding material. The curcumin/cyclodextrin polymer supramolecular inclusion compound prepared by the invention is proved to be formed by DSC, FT-IR and XRD identification, and has better water solubility compared with the traditional curcumin/cyclodextrin inclusion compound. Meanwhile, the invention adopts HPLC as a method for detecting curcumin content, and has the advantages of strong specificity, high sensitivity, good repeatability, convenient operation and the like. The preparation method is simple, the obtained inclusion compound yield and inclusion rate meet the requirements of production and clinical application, and have better application prospect.curcumin 3427 cyclodextrin polymer 1510 physical mixture 1035 2922 4000 3600 3200 2800 2400 2000 1600 1200 800 400 d (cm1) Figure 3 8.78 17.13 7.83 15.79 13.76 inclusluSon CommplX03 5 10 15 20 25 30 35 40 45 50 55 Figure 4 2/2