USE OF MICROVESICLES IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF MEDICAL DISEASES AND CONDITIONS

摘要

#$%^&*AU2020201821A120200402.pdf#####ABSTRACT The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a' subject by detecting a biomarker in microvesicles isolated from a biological, sample from the subject. Moreover, disclosed subject matter is directed to methods of diagnosis, monitoring a disease by determining the concentration of microvesicles within a biological sample; methods of delivering a nucleic acid or protein to a target all by administering microvesicles that contain said nucleic acid or protein; methods for performing a body fluid transfusion by introducing a microvesicle-free or microvesicle enriched fluid fraction into a patient.WO 2009/100029 PCT/US2009/032881 1/28 a b c d " .....R.ase.treated..... ... ... ... . ... ... . .. ... .... .... .... .. .. ... ... ... ... .... .... .... .... ... '... ... '...N ... N IN ..... .~~~~~~ ~ .. ................... ..................................... .. .... . . . .. . . . . . . . . . . . . . .. . . . . . . ..X. . . . . ..... .......................... F IG............. . 1 a -e...................