Formulation for use in the treatment of uremic pruritus

摘要

#$%^&*AU2020202785A120200514.pdf#####ABSTRACT There is provided a topical formulation comprising a nucleophile, such as amino acids and most polypeptides and/or a derivative thereof, for use in the treatment or prevention of itchy dry skin caused by urea, such as in uremic pruritus, of a subject. The amino acid may be histidine and the derivative may be a histidine degradation product, a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceuticallyacceptable salt of histidine.