PROCESS FOR PREVENTING OR LIMITING MICROBIAL CONTAMINATION DURING CONTINUOUS CULTURE

摘要

Long term or continuous fermentation processes are susceptible to contaminating by microorganisms that can lead to decreases in efficiency. The present disclosure provides a process for limiting a microbial contamination (between 0.1-10%) during a continuous culture of a recombinant yeast host cell in a medium. The process is based on the use of a combination of a recombinant yeast host cell having a genetic modification for reducing the expression of a noxious gene capable of converting a pro-cytotoxic agent into a cytotoxic agent and a pro-cytotoxic agent.