Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of Amyotrophic Lateral Sclerosis (ALS)

摘要

#$%^&*AU2020244551A120201029.pdf#####ABSTRACT OF THE DISCLOSURE The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.