SCREENING ASSAYS, MODULATORS AND MODULATION OF INTRACELLULAR SIGNALLING MEDIATED BY IMMUNOGLOBULIN SUPERFAMILY CELL ADHESION MOLECULES

摘要

The invention relates to modulators of activation of Immunoglobulin Superfamily Cell Adhesion Molecules (IgSF CAMs) and modulators of activation of Receptor for Advanced Glycation End Products (RAGE) as well as screening assays for identifying modulators of activation of molecules associated with certain diseases and/or conditions in which IgSF CAMs and/or RAGE are implicated, and to medicaments and methods of treatment comprising administration of such modulators.