Provided are a cross-barrier focus-targeting drug delivery system, a carrier system and a host cell system. The drug delivery system comprises cross-barrier virus-like particles and focus-targeting virus-like particles, wherein the cross-barrier virus-like particles carry cross-barrier signals, the focus-targeting virus-like particles carry focus-targeting signals, and the cross-barrier virus-like particles and the focus-targeting virus-like particles can form heteropolymeric virus-like particles by means of self-assembly.
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