DYNAMICS WITHIN SUPRAMOLECULAR 1KVAV MATRICES ENHANCE FUNCTIONAL MATURATION OF HUMAN IPSCS-DER1VED NEURONS AND REGENERATION

摘要

Provided herein are peptide amphiphiles (PAs) comprising a bioactive peptide, nanofibers displaying the bioactive PAs, and methods of use thereof. The disclosed peptide amphiphiles comprise a hydrophobic tail, a structural peptide segment, a charged peptide segment, and a bioactive IKVAV peptide. The disclosed PAs may be used in cell culture methods and in methods of treating central nervous system injury.