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NUCLEIC ACID SEQUENCE ENCODING CHIMERIC ANTIGEN RECEPTOR AND A SHORT HAIRPIN RNA SEQUENCE FOR IL-6 OR A CHECKPOINT INHIBITOR
NUCLEIC ACID SEQUENCE ENCODING CHIMERIC ANTIGEN RECEPTOR AND A SHORT HAIRPIN RNA SEQUENCE FOR IL-6 OR A CHECKPOINT INHIBITOR
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机译:IL-6或检查点抑制剂编码嵌合抗原受体和短发RNA序列的核酸序列。
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摘要
The present invention is directed to a nucleic acid sequence comprising: (a) a first polynucleotide encoding a chimeric antigen receptor (CAR) fusion protein comprising from the N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) comprising VH and VL, wherein scFv specifically binds to a tumor antigen, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain; and (b) a second polynucleotide encoding an IL-6 short hairpin RNA (shRNA) sequence, or a check point inhibitor shRNA, wherein the check point inhibitor is PD-1, CTLA-4, TIM-3, TIGIT, or LAG-3.
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机译:本发明涉及一种核酸序列,其包含:(a)编码包含从N末端到C末端的嵌合抗原受体(CAR)融合蛋白的第一多核苷酸:(i)单链可变片段(scFv )包含V H Sub>和V L Sub>,其中scFv特异性结合肿瘤抗原,(ii)跨膜结构域,(iii)至少一个共刺激结构域和(iv)激活域; (b)编码IL-6短发夹RNA(shRNA)序列或检查点抑制剂shRNA的第二个多核苷酸,其中检查点抑制剂为PD-1,CTLA-4,TIM-3,TIGIT或LAG- 3。
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