REGIO-SPECIFIC BIODEGRADABLE NANOGELS FOR CARGO DELIVERY PLATFORM

摘要

The disclosed technology is directed to regio-specific biodegradable nanogel compositions, and methods of manufacturing and using the same. Specifically, the disclosed technology includes customizing a nanogel network structure with degradable linkages to create a nanogel that is suitable for dmg delivery or tissue scaffold applications. An exemplary nanogel includes a mono-vinyl monomer, a di-vinyl monomer, a chain transfer agent, and an initiator, wherein at least one of the mono-vinyl monomer and the di-vinyl monomer includes a degradable linkage, and the degradable linkage is positioned at a location within the nanogel and/or between covalently interconnected nanogels such that there is selected control of the rate of degradation of the nanogel and/or release of nanogel-contained cargo.