Fluorescent Probes for Singlet Oxygen Generation and Cancer Ablation

摘要

A fluorescent probe can include a compound exhibiting near infrared (NIR) aggregation-induced emission (AIE). The probe can be used for the selective imaging and killing of cancer cells. The probe can specifically stain mitochondria and selectively target cancer cells over normal cells. The probe exhibits strong near-infrared (NIR) two-photon absorption (2PA), bright NIR emission and efficient singlet oxygen ( ¹O ₂) generation. The probe can be used both in cancer cell-selective ablation and in in vivo melanoma therapy using image-guided PDT.