METHOD OF PREPARING A DON PRODRUG FROM L-PYROGLUTAMIC ACID

摘要

The present disclosure provides a method of preparing a compound of Formula I, wherein R¹ is C₁-C₄ alkyl; R² is C1-C4 alkyl; and R³ is selected from the group consisting of C₁-C₆ alkyl, (aryl)alkyl, and (heteroaryl)alkyl in 95% chemical purity and 95% enantiomeric excess.