TREATMENT OF PROSTATE CANCER BY ANDROGEN ABLATION AND IL-8 BLOCKADE

摘要

A method of treating prostate cancer by administration of an IL-8 blocker in combination with androgen ablation. The inventors have surprisingly discovered that androgen ablation (such as ADT) results in the secretion of IL-8 from prostate epithelial cells. IL-8 is a potent chemoattractant that recruits and maintains immune cells with suppressive properties, such as myeloid derived suppressor cells (MDSCs)