SALICYLIC ACID BERBERINE-TYPE ALKALOID QUATERNARY AMMONIUM COMPOUND AND USE THEREOF FOR PREPARING MEDICINES

摘要

Disclosed in the present invention are a salicylic acid berberine-type alkaloid quaternary ammonium compound as shown in general formula (I), a preparation method therefor, solubility characteristics, a pharmaceutical composition and an application thereof in the preparation of medicinal products. The salicylic acid berberine-type alkaloid quaternary ammonium compound as shown in general formula (I) may be prepared by an organic synthesis method, and shows obvious solubility of alcohol-water mixed solvents. The compound may be conveniently prepared on a large scale, and has significant anti-ulcerative colitis activity, with non-toxic or low toxicity characteristics. The compound may be used to prepare products for preventing, relieving and/or treating ulcerative colitis.