PREPARATION METHOD FOR IONIC BOND-COVALENT BOND SYNERGY-BASED SURFACE HEPARINIZED ANTICOAGULANT MEDICAL DEVICE

摘要

A preparation method for an ionic bond-covalent bond synergy-based surface heparinized anticoagulant medical device. In said method, firstly, a hydrophilic polymer of which the side chain is modified by a low molecular weight hyperbranched polyethyleneimine is used to fix heparin on the surface of a medical device by means of ionic bonding, and further, a stable heparin coating is grafted by means of covalent bonding, so as to obtain an anticoagulant biomedical device having high anticoagulant activity and high anticoagulant stability.