INTEGRIN ΑVΒ3 TARGETING PROBE FOR DIAGNOSING RETINAL AND CHOROIDAL NEOVASCULAR DISEASES, AND PREPARATION METHOD THEREFOR

摘要

Provided are: an integrin targeting probe, which can be effectively used for the diagnosis or treatment of retinal and choroidal neovascularization or age-related macular degeneration by predicting the occurrence and recurrence of retinal and choroidal neovascularization before structural changes of retinal and choroidal neovascularization occur; and a preparation method therefor. The integrin targeting probe is an integrin α_vβ₃ targeting probe for diagnosing retinochoroidal neovascular diseases and can comprise a fluorescence-labeled cyclic RGD peptide, which is completed by conjugating an NH₂-cyclic RGD peptide precursor to a fluorescent material.