MULTITARGET COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

摘要

The invention provides compounds of formula I wherein: m is 0, 1 or 2; n is 2, 3, 4 or 5; R₀ and R₁ are both H, or they form a bridge -CH₂-C(R₄ )=CH-, R₄ being CH₃ or CH₂CH₃; R₂ and R₃ independently are H, F, Cl or (C₁-C₄)-alkyl; R₅ is H, F, Cl, Br, I, OCH₃, OCF₃, SF₅, SO₂F, SO₂CH₃, NO₂, CF₃ or (C₁-C₄)-alkyl; R₆ and R₇ independently are H, F, Cl, CH₃ or CF₃; and optionally R₅ and R₆ form a bridge -O-CH₂ -O-, R₇ being H, invitro assays show that compounds I are simultaneously inhibitors of acetylcholinesterase and inhibitors of soluble epoxide hydrolase, and that they have a good blood-brain barrier permeability. Thus, compounds I are multitarget active pharmaceutical ingredients for the treatment of Alzheimer's disease in humans.