TOPICAL ORAL AND/OR SYSTEMIC ORAL FORMULATIONS CONTAINING A MIXTURE BASED ON LACTOFERRIN, MORE EFFICACIOUS IN IRON UPTAKE, FOR THE PREVENTION AND TREATMENT OF SEVERAL PATHOLOGIES

摘要

Mixture containing lactoferrin, sodium citrate and sodium bicarbonate and whose molar ratio intended as moles of lactoferrin/ (moles of sodium citrate+ moles of sodium bicarbonate) is between 10"4 and 10"3 for use in the treatment of infections colonising the epithelia in the oral mucous membranes for the purpose of: • decreasing the number of pathogenic microorganisms, including those associated with tooth pigmentation such as black stains, • inhibiting the formation of biofilm, • inhibiting the microbial ability to adhere and invade, • helping injury repair, • inhibiting or decreasing the inflammatory process caused by infections optionally associated with iron deficiency, anaemia, inflammation anaemia or diabetes. The mixture is administered only topically in the form of an oral topical formulation in the absence of iron homeostasis disorders or the oral topical formulation is administered in combination with a systemic oral formulation including lactoferrin, sodium citrate and sodium bicarbonate in the same molar ratio range as above, when these infections and the associated inflammatory process in the oral mucous membranes are associated with iron deficiency, anaemia or inflammation anaemia, or when the inflammatory process is associated with diabetes.