ULTRAFINE IRON OXIDE NANOPARTICLE-BASED MAGNETIC RESONANCE IMAGING T1 CONTRAST AGENT

摘要

Provided is a magnetic resonance imaging T1 contrast agent comprising: a fine iron oxide nanoparticle core; and a micelle for encapsulating the core particles, wherein the micelle comprises a non-ionic surfactant containing: a hydrophilic residue containing at least two chains; and a hydrophobic residue consisting of at least one C10-C30 hydrocarbon chain. The magnetic resonance imaging T1 contrast agent of the present invention is a novel fine iron oxide nanoparticle-based T1 contrast agent that can replace conventional gadolinium-based T1 contrast agents, is not harmful to the human body due to being based on iron oxide nanoparticles, and exhibits a uniform contrast effect due to rapid distribution in blood and the uniform size. In addition, the contrast agent enables image observation for 1 hour or longer, or up to a maximum of 2 hours or longer and is excreted through the kidneys and liver, and thus can address the problems of conventional gadolinium-based contrast agents.