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SOLID NANOPARTICLE FORMULATION OF WATER INSOLUBLE PHARMACEUTICAL SUBSTANCES WITH REDUCED OSTWALD RIPENING AND IMMEDIATE DRUG RELEASE FOLLOWING INTRAVENOUS ADMINISTRATION
SOLID NANOPARTICLE FORMULATION OF WATER INSOLUBLE PHARMACEUTICAL SUBSTANCES WITH REDUCED OSTWALD RIPENING AND IMMEDIATE DRUG RELEASE FOLLOWING INTRAVENOUS ADMINISTRATION
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机译:静脉给药后减少油脂挥发和立即释放药物的水不溶性药物的固体纳米颗粒配方
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摘要
The present invention provides a composition comprising solid nanoparticles wherein the solid nanoparticles comprise i) an effective amount of a first therapeutically active agent; ii) an effective amount of one or more additional therapeutically active agents; and iii) a biocompatible polymer wherein the one or more additional therapeutically active agents is sufficiently miscible with the first therapeutically active agent to form solid particles, wherein the particles comprise a substantially single-phase mixture of the first therapeutically active agent and the one or more additional therapeutically active agents.
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