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VIRUS COMPOSITIONS WITH ENHANCED SPECIFICITY IN THE BRAIN
VIRUS COMPOSITIONS WITH ENHANCED SPECIFICITY IN THE BRAIN
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机译:脑中特异性增强的病毒成分
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摘要
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摘要
Provided are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell-types, for e.g., the brain and the liver. Therapeutic and biomedical research applications of the rAAVs are also described, including without limitation methods of discovering rAAVs using a multiplexed Cre recombination-based AAV targeted evolution (M- CREATE) method, and methods of treating various diseases and conditions by rAAV-mediated transgene therapy.
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