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MULTI-COMPONENT PHARMACEUTICAL SINGLE DOSAGE FORMS AND METHODS EMPLOYED THEREOF
MULTI-COMPONENT PHARMACEUTICAL SINGLE DOSAGE FORMS AND METHODS EMPLOYED THEREOF
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机译:多组分药物单一剂量形式及其应用方法
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摘要
Exemplary embodiments of the present disclosure are directed towards multi-component pharmaceutical single dosage forms and methods employed thereof. The multi-component pharmaceutical single dosage form comprising: a plurality of sub-units comprising a body piece and a cap piece, wherein the body piece is a capsule shaped or cup shaped tablet piece filled with a powder selected from an active drug substance blend, and the cap piece compressed in pre-determined dimensions with suitable punches to provide the multi- component pharmaceutical single dosage form. The advantage of the dosage form disclosed herein is that the active ingredient blend is not subjected to compression forces of tablet. Also lubricant, binder or disintegrant concentrations required in the blend is lower compared to conventional tablet dosage forms. These provide better scale up process with less quality issues.
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