STABILIZATION OF PRANDIAL OR BASAL INSULIN ANALOGUES BY AN INTERNAL DISELENIDE BRIDGE

摘要

Disclosed herein are insulin analogues containing a pairwise substitution of cysteine at positions A6 and A11 with selenocysteine residues such that a diselenide bridge forms between these positions. The disleenide bridge of the [Sec^A6, Sec^A11] insulin analogues stabilizes the analogue relative to its [Cys^A6, Cys^A11] parent structure, providing formulations with extended shelf life at or above room temperature. Also provide are methods of treating diabetes mellitus using the [Sec^A6, Sec^A11] insulin analogue.