COMBINATORIAL CAR T CELL AND HEMATOPOEITIC STEM CELL GENETIC ENGINEERING FOR SPECIFIC IMMUNOTHERAPY OF MYELOID LEUKEMIAS

摘要

Some embodiments of the methods and compositions provided herein include chimeric antigen receptors (CAR)s which specifically bind to an epitope of CD33, such as an epitope encoded by exon 2 of CD33. Some embodiments include the use of such CARs for effective and safe therapies for myeloid leukemias, such as acute myeloid leukemia and chronic myeloid leukemia.