COMPONENT AND METHOD FOR PROTECTING AND TREATING DRUG-INDUCED LIVER INJURY

摘要

Disclosed is the use of a chitosan oligosaccharide (COSM) with a molecular weight less than or equal to 3000 in the preparation of a composition for protecting and treating drug-induced liver injury. In particular, the use thereof in the preparation of a composition for protecting and treating acetaminophen-induced liver injury is disclosed. Further disclosed is a method for protecting and treating drug-induced liver injury, the method comprising administering an effective amount of a COSM to a subject with liver injury. Experiments prove that the COSM can regulate abnormalities of biochemical indicators of liver function induced by acetaminophen; significantly reduce the abnormal elevation of ALT and AST in mouse serum induced by acetaminophen; improve liver tissue injury induced by acetaminophen; increase the content of glutathione (GSH), a detoxicant, in liver tissue affected by acetaminophen-induced liver injury; increase the oxidation resistance of liver affected by acetaminophen-induced oxidative injury; and reduce the content of malondialdehyde (MDA) of acetaminophen-induced liver oxidative injury. The COSM is expected to be developed and applied to treating liver injury caused by clinical treatment drugs, which provides a better choice for patients.